PERSON DIRECTORY
Alex Rives
Alex Rives appears in 3 indexed conversations across Latent Space, No Priors, The Cognitive Revolution. This directory brings every appearance, source, TL;DR, digest, and transcript into one searchable feed.
A World Model of Life: Biohub's Alex Rives on Virtual Cells, Measurement, & the $1.8B Data Push
Biohub’s $1.8B initiative joins the Department of Energy, NIH, Google DeepMind, Isomorphic Labs, and Meta to map molecular readouts and imaging.Rives calls observability a fundamental bottleneck; a laser phase plate adds phase contrast in cryo-electron tomography, but virtual cells still cannot meaningfully simulate cells.Atlas drafts target one or two years, with a comprehensive map within five.
Biohub: The Future of Biology is Open-Source with Zuckerberg & Chan
Elad GilSarah GuoMark ZuckerbergPriscilla ChanAlex Rives
Biohub’s $500 million, 10- to 15-year commitment targets purpose-built biological data, combining frontier AI with wet labs from proteins to cells and whole systems.ESMfold predicted structures for more than 1.1 billion proteins and produced nanomolar binders from 96 synthesized designs without antibody-specific training, while open release could accelerate research but leaves biosafety and clinical translation unresolved.
🔬 The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub
ESM-C’s key advance was billions of diverse metagenomic sequences, which restored scaling returns at roughly ESM-2’s parameter scale and enabled an MIT-licensed atlas of 6.8 billion proteins.Search-based design produced scFvs reaching therapeutic thresholds in a small number of trials, but full IgG remains untested as Biohub builds the data stack with $400 million internally and $100 million externally.